Researchers discover CBC & CBG Can Kill Gastrointestinal Cancer Cells


Studies have found that two previously unsung cannabinoids can cause necrosis in human gastrointestinal cancer cells.

Cannabics Pharmaceuticals, a medical cannabis firm in the US, and it's Israeli R&D department have released the results of a pre-clinical test suggesting that the cannabinoids CBC (cannabichromene) and CBG (cannabigerol) can help destroy tumors. The tests, which were conducted at the company's High Throughput Screening (HTS) lab facilities in Israel, found that CBC and CBG can cause significantly higher rates of necrosis in human gastrointestinal cancer cells compared to other cannabinoids.

"Gastrointestinal cancers are amongst the leading and most wide-spread causes of cancer-related deaths worldwide,” said Dr. Eyal Ballan, CTO and co-founder of Cannabics, in a statement. “We are intrigued by the results we have obtained in the lab, and our aim is to consider placing an emphasis on this organ system, and to further explore the differential anti-tumor properties of cannabinoids."

The study also found that CBG had a stronger anti-tumor effect on human stomach and bone cancer cells than CBGA, the acidic form of CBG. Dr. Yaakov Waksman, head of cannabidiol research at Cannabics, believes that “CBC and CBG, as neutral cannabinoids,” have an attribute “which allows the cannabinoid molecule to penetrate a cancer cell's membrane, whereas their acidic form (CBCA and CBGA) do not. This could explain the difference in anti-tumor activity rates demonstrated.”

People know about THC and CBD, the most thoroughly researched cannabinoids, but there are a host of other natural compounds within the marijuana plant — many that have unique health benefits. CBC, a non-psychoactive compound, occurs mostly in younger cannabis plants, but often in small quantities. Preliminary studies have found that CBC can have antimicrobial, anti-inflammatory, and analgesic properties.

CBG, the other non-psychoactive cannabinoid, is also found in small quantities within the cannabis plant. It has also been found to have anti-bacterial, anti-inflammatory, and tumor-killing properties. A recent study even found that CBG could help kill antibiotic-resistant “superbugs” that have infected a growing number of patients at hospitals around the world.

“CBG is gaining a lot of interest as of late by the scientific community due to its potential therapeutic properties,” said Dr. Waksman in an interview with Oracle Dispatch.

“The recent preliminary findings from our research team illustrate how purified cannabinoids can potentially yield anti-tumor activity and enable us to examine the entourage effect of botanical extracts versus the purified compounds,” Waksman concluded. Cannabics is planning to conduct additional clinical trials that will seek to find out whether these natural cannabis compounds could effectively treat patients with gastrointestinal cancer.


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